Manchester City eased past Swindon Town 4-1 to reach the fourth round of the FA Cup, while Manchester United beat Burnley 2-0 and Tottenham were stunned by League Two side Morecambe.
Manchester City made a host of changes to their team but were still too strong for League Two Swindon, with goals from Bernardo Silva, Gabriel Jesus, Ilkay Gundogan and Cole Palmer sealing their victory.
Manchester United were more laboured in their win over Burnley, but goals from Scott McTominay and Jadon Sancho were enough to see them through.
Tottenham were the biggest victims of an upset on Saturday, as they were beaten 1-0 by League Two Morecambe.
A stoppage-time goal from Anthony O’Connor earned Morecambe a famous victory over the Premier League side.
In other FA Cup action, Liverpool beat Shrewsbury Town 4-1, Chelsea beat Chesterfield 5-1, and Arsenal beat Oxford United 2-0.
The fourth round draw will take place on Monday night.
Manchester City will be at home to Fulham, Manchester United will be away to Middlesbrough, and Tottenham will be away to Brighton.
Liverpool will be at home to Cardiff City, Chelsea will be away to Plymouth Argyle, and Arsenal will be at home to Nottingham Forest.
The fourth round matches will be played on the weekend of February 5th and 6th.
FA Cup fourth round draw in full:
Wrexham vs Sheffield United
Tottenham vs Brighton
Boreham Wood vs Bournemouth
Burnley vs Huddersfield Town
Peterborough United vs QPR
West Ham vs Kidderminster Harriers
Manchester United vs Middlesbrough
Liverpool vs Cardiff City
Luton Town vs Cambridge United
Chelsea vs Plymouth Argyle
Bristol City vs Fulham
Manchester City vs Fulham
Tottenham vs Brighton
Stevenage vs Swindon Town
Aston Villa vs Barrow
Crystal Palace vs Hartlepool United
Walsall vs Leicester City
Blackburn Rovers vs Birmingham City
Arsenal vs Nottingham Forest.
